Aim. The purpose of this study was to review the effectiveness of new cardiac biomarkers.

Background. Cardiovascular diseases have been a heavy burden on the health system’s shoulders and caused about 30 percent of human's deaths annually. Irreversible myocardial injury occurs within around 15-20 minutes following the coronary artery occlusion. Therefore, early diagnosis of this problem is very important for the health care professionals to save patients’ lives. Nowadays, thanks to recognition of new biomarkers and using their characteristics, evaluating the short-term and long-term prognosis is possible.

Method. In this study, papers published within the time period 1980 to 2014, were considered. The papers  were searched out by the keywords “cardiac biomarker”, “new cardiac markers”, “coronary diseases”, and “cardiovascular diseases” in Elsevier, Google Scholar, JAMA, Science Direct, Wiley, PubMed, and Iran Medex databases.

Findings. The results indicate that characteristic of each biomarker can play an important role to advance the goals of medicine and harm reduction in the cardiovascular patients. However, despite the high efficiency, routine usage of them is still unclear which indicates the need for further research in this field.

Conclusion. New biomarkers provide new insight about recognition of the causes of cardiovascular diseases, also their easy and rapid application with high sensitivity and predictive value will develop a dramatic change in the diagnosis and treatment of patients with cardiovascular diseases.